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H a natural inhibitor consumption. Many studies have evidenced validity of
Results During the period of observation, 215 patients were admitted to the ICU (57.5 male), with a median age 65.0 years (IQR 54?7) and APACHE II score 14.0 (IQR 10.0?9.0). One hundred and seventy-six subjects (81.9 ) were alive after a 14day follow-up. Seventy patients (32.6 ) developed thrombocytopenia during the study. Patients who ever developed thrombocytopenia had a higher ICU mortality (28.6 vs 13.0 , respectively; P < 0.006) and a higher consumption of blood products (24 vs 2 , P < 0.0001). However, both groups had the same APACHE II score (15.15 ?6.1 vs 15.15 ?7.2, P = 0.99) and ICU stay (8.2 ?7.1 vs 8.4 ?12.8, P = 0.93). Conclusions Even in an ICU sample with a low risk of death predicted by the APACHE II score, thrombocytopenia was highly associated with higher mortality and consumption of blood products.H a natural inhibitor consumption. Many studies have evidenced validity of antithrombin (AT) CS-3074 web treatment during preeclamptic conditions. The aim of the study is to restore a congruous coagulation imbalance with administration of AT under the guide of thromboelastographic monitoring (TEG). Methods Ten preeclamptic pregnant women in the 24th?0th weeks with diastolic blood pressure >90 mmHg and urinary protein level 24 hours >0.3 g were included. All patients were submitted to a complete study of coagulation function: prothrombin time (PT), activated partial thromboplastin time (aPTT), International Normalization Ratio (INR), fibrinogen C, D-dimer, AT and TEG at the beginning, after every administration of AT, weekly until caesarean section, and daily for 1 week in the postoperative period. AT was administered every time the AT plasmatic level was less than 80 to restore the plasmatic level to more than 120 using the following algorithm: (120 ?AT plasmatic level) x kg. At the beginning, only seven patients were treated with AT. Results At the beginning, all patients showed AT consumption and a hypercoagulation TEG (Figure 1), but the INR and aPTT were in the normal ranges. Patients treated with AT at the beginning did not need a new administration. AllP214 Thrombocytopenia is associated with mortality in hospitalized patients with low risk of deathM Oliveira, R Gomes, L Silva, F Ribeiro, C Boaventura, A MedChemExpress Forodesine (hydrochloride) Camelier, R Passos, D Flores, J Teles, A Farias, O Messeder Hospital Portugues, Salvador Bahia, Brazil Critical Care PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28952188 2008, 12(Suppl 2):P214 (doi: 10.1186/cc6435) Introduction Thrombocytopenia is inversely related to survival in critical care patients [1].H a natural inhibitor consumption. The objective of the present study was to evaluate the prevalence of thrombocytopenia PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28103888 in patients of an ICU and to determine whether it might be a significant predictor of outcome. Methods A prospective observational cohort study was performed from April to September 2007 in a 24-bed medical urgical ICU. All patients admitted to the ICU during the period of observation were included in the study. Patients were prospectively studied until 14 days from admission, discharge from the ICU, or death.H a natural inhibitor consumption. Many studies have evidenced validity of antithrombin (AT) treatment during preeclamptic conditions.
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