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Solation. Sizeable variables connected independently with Aspergillus spp. isolation were being arterial
colonization had been an AECOPD while in the preceding 12 months, along with the concurrent isolation of PPMs, most often Pseudomonas aeruginosa. Notably, Aspergillus spp. isolation wasn‘t associated with additional ACY-1215 critical exacerbations or even worse scientific results following a one-year observe up. We found 28 Aspergillus spp. isolates working with a normal approach for mycological investigations in spontaneous sputum samples. The prevalence price of fourteen.4 within our COPD cohort following a one-year follow-up was remarkably substantial. In reality, Aspergillus spp. isolation may have been ACY-1215 site greater if we had utilised bronchoscopic strategies and specific tradition media.Solation. Major variables connected independently with Aspergillus spp. isolation were being arterial hypertension (OR 4.72; 95 private interval (CI), 1.56-14.29; p < 0.001), COPD exacerbation that required hospitalization inTable 4 Significant univariate and multivariate logistic regression analysis for the prediction of Aspergillus spp. risk factorsUnivariate analysis OR Arterial hypertension Cardio vascular disease Diabetes mellitus Chronic renal disease COPD exacerbation in the previous year ?Previous bacterial colonization Concurrent PPM isolation??Multivariate analysis p-value 0.032 0.027 0.041 0.070 0.050 0.002 0.024 0.042 OR 4.72 12.35 3.64 2.80 95 CI 1.56-14.39 1.87-29.14 1.65-9.45 1.81-11.42 p-value 0.001 <0.001 0.001 0.95 CI 1.17-35.84 1.30-76.47 1.77-15.94 2.23-15.35 1.16-6.11 1.47-8.37 1.42-6.84 1.21-5.6.48 9.97 3.52 2.92 2.60 3.50 2.92 2.?Concurrent P. aeruginosa isolationCOPD exacerbation that required hospital management (emergency room visit or admission). PPM, Pathogenic microorganisms.Huerta et al. Respiratory Research 2014, 15:17 http://respiratory-research.com/content/15/1/Page 7 ofthe last year (OR 12.35; 95 CI, 1.87-29.14; p < 0.001), concurrent PPMs isolation (OR 3.64; 95 CI, 1.65-9.45; p = 0.001), and concomitant isolation on the same sample of Pseudomonas aeruginosa (OR 2.80; 95 CI, 1.81-11.42; p = 0.001).Short-term and long-term clinical outcomesThe short- and long-term clinical outcomes are shown in Table 2. Patients with Aspergillus spp. isolation had significantly higher LOS compared to those patients without Aspergillus spp. isolation (7.5 ?5.0 days Aspergillus versus 11.8 ?9.2 days Aspergillus, p = 0.02). No differences were found in the rate of exacerbations within the first month (24 versus 25 ; p = 0.54) or during the follow-up (60 versus 54 ; p = 0.34). The overall mortality rate at 12 months was 11.3 (27 patients); 13 (10.8 ) in the non-Aspergillus spp. group and three (12.5 ) in the Aspergillus spp. group (p = 0.373).Discussion This is the first study to date to prospectively determine the prevalence of airway Aspergillus spp. and examine the associated risk factors for isolation, in a cohort of severe COPD patients requiring hospitalization for an AECOPD. We have shown that the prevalence of Aspergillus spp. isolation in this cohort was 16.6 on admission and 14.4 at the end of one-year follow-up.
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