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And C. glabrata were isolated in either study, MIC values of
BMC Oral CS682 In Vitro Health 2014, 14:14 http://www.biomedcentral.com/1472-6831/14/Page 4 ofTable 1 Background variables of patients with oral candidiasis enrolled in the 2006?007 and 2012?013 studies2006-2007 Subjects number Gender Total Male Female Age Chief Complaints Average [Anti-Flag Magnetic Beads Protocol max-min] Heat sensation(HS) Taste abnormality (TA) Xerostomia (X) Tylosis linguae (TL) Rubor/Erosion (R/E) HS + TA + X HS + TA + R/E HS + TL Total Systemic disease Yes None Total Endocrine Cardiovascular Gastrointestinal Malignant tumor CNS Viral Autoimmune Total Steroid Dose Non-dosed Total Denture Wearer Non-wearer Total Oral candidiasis Pseudomembranous Erythematous Hypertrophic Mixed Total 19 38 67.9 23 2 5 4 4 9 5 5 57 44 13 57 22 18 123 8 4 6 5 75 12 45 57 37 20 75 42 11 2 2 55 57 (33.3) (66.7) [26?0] (40.4) (3.5) (8.8) (7.0) (7.0) (15.8) (8.8) (8.8) (100) (77.2) (28.8) (100) (29.3) (24.0) (16.0) (10.7) (5.3) (8.0) (6.7) (100) (21.1) (78.9) (100) (64.9) (35.1) (100) (73.7) (19.3) (3.5) (3.5) (100) 30 82 69.6 46 0 26 0 8 16 8 8 112 97 15 112 22 28 12 12 10 8 35 127 28 84 112 57 55 112 42 52 4 14 112 2012-2013 112 (26.8) (73.2) [21?7] (41.1) (0) (23.2) (0) (7.1) (14.3) (7.1) (7.1) (100) (86.6) (13.4) (100) (17.3) (22.0) (9.4) (9.4) (7.9) (6.3) (27.6) (100) (25.0) (75.0) (100) (50.9) (49.1) (100) (37.5) (46.4) (3.6) (12.5) (100) Fisher‘s exact probability test [2 ?2] N.S.And C. glabrata, were not reliable. Therefore, the results PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26725367 of susceptibility testing mainly refer to the MICs of C. albicans and C. glabrata (Table 3).Amphotericin B (AMPH-B)Classification of diagnosed OC cases is also shown in Table 1. Among the 57 patients in the PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25085711 2006?007 study, OC was most frequently classified as pseudomembraneous OC (73.7 ), followed by erythematous OC (19.3 ). In the 2012?013 study, however, erythematous OC accounted for half (46.4 ) of OC cases, followed by pseudomembranous OC (37.5 ) and mixed OC (erythematous and pseudomembranous, 12.5 ), but no statistical difference was noted.The MIC was found to be low (2 g/mL) in 63 (96.9 ) of the 65 strains in the 2006?007 study and in 153 (99.4 ) of the 154 strains in the 2012?013 study. Two strains of C. albicans in the 2006?007 study and 1 strain of C. glabrata in the 2012?013 study demonstrated high MIC of over 16 g/mL. However, the presence of resistant strains could not be detected in the concentration range used in this analysis. There was no obvious difference in the susceptibility of the 2 main Candida species, C. albicans and C. glabrata, between the 2 studies, with MIC90 values of 0.5 g/mL and 2.0 g/mL, respectively, in the 2006?007 study and of 1.0 g/mL and 1.0 g/mL, respectively, in the 2012?2013 study.Kamikawa et al.
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