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His relationship was not statistically significant, and our study is in
His relationship was not statistically significant, and our study is in line with the previous published studies.19 Following invasive ductal carcinomas, carcinoma in situ had the highest frequency of HER2/neu overexpression. In a study conducted by Latta et al, 50 to 60 of noninvasive carcinomas had HER2/neu overexpression, and given that HER2/neu S dropped onto clean slides. The dried preparation was stained with overexpression in this group is associated with a higher prevalence of local relapse.20 In our study, cases of breast cancer with HER2/neu overexpression were mostly younger than age 50; however, no significant relationships were found between the 2 parameters. The present study was consistent with other studies in that HER2/neu overexpression was mainly observed in patients <50.21,22 In the present study, HER2/neu overexpression increases with tumor grade, suggesting the higher likelihood of HER2/neu expression at higher grade tumors, thereby causing the tumors to be more invasive and more likely to relapse. Similar studies also showed the increase in HER2/neu overexpression with tumor grade.22,5 Another prognostic factor of breast cancer is tumor grade; higher tumor grades are associated with an increased degree of relapse, greater extent of involvement, and higher chance of distant metastasis.23,24 In the present study, grade 2 tumors were more prevalent than the other tumor grades (1 and 3), and lobular carcinomas had the highest frequency of grade 2 tumors, followed by invasive ductal carcinomas. The comparison of the different types of carcinomas showed that medullary carcinomas had the highest frequency of grade 3 tumors, and although high grade in appearance, this carcinoma acts as a low-grade tumor that does not progress rapidly and involves regional lymph nodes to a lesser degree.25 The present study showed a significant relationship between tumor grade and the extent of lymph node involvement. The highest levels of lymphCopyright#node involvement were observed in grade 3 carcinomas. Moreover, the present study showed that lobular carcinomas were expressed with higher levels of lymph node involvement, followed by invasive ductal carcinomas; and although medullary carcinomas had a higher grade, their level of lymph node involvement was lower compared with lobular and ductal carcinomas; however, the difference was not statistically significant. Among all types of carcinomas, tubular carcinomas had the optimum grade (grade 1) and the lowest level of lymph node involvement and are therefore accompanied by the best prognosis and the least level of distant metastasis and local relapse.25 Ki67 was considered as a prognostic factor; in literature review high index labeled Ki67 is considered an unfavorable factor that influences tumor progression and is associated with poorer prognosis.26 In the present study, medullary carcinomas had the highest rate of Ki67 expression, followed by mucinous carcinomas, although both these carcinomas showed a lower degree of local Esicles had been formed by a monolayer of relapse and lymph node involvement compared with the other carcinomas. These 2 carcinomas showed a statistically significant difference with the other types of carcinomas in their Ki67 status, although higher levels of Ki67 indicate the invasive nature of the tumor and entail a worse prognosis. A significant relationship was also found between Ki67 and tumor grade, as tumors with higher grades have higher levels of cell proliferation and are consequently more invasive than the other grades; these findings were consistent with the.His relationship was not statistically significant, and our study is in line with the previous published studies.19 Following invasive ductal carcinomas, carcinoma in situ had the highest frequency of HER2/neu overexpression.
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